<p>Democratic presidential nominee Hillary Clinton shakes hands with Republican presidential nominee Donald Trump as Moderator Lester Holt looks on during the Presidential Debate at Hofstra University on September 26, 2016 in Hempstead, New York.</p>
Democratic presidential nominee Hillary Clinton and Republican nominee Donald Trump will take the debate stage tonight in a heavily anticipated matchup.
But who will come out on top?
The debate is scheduled to start at 9 p.m. ET and will last 90 minutes. NBC Nightly News anchor Lester Holt will moderate the debate.